Saving a purchase invoice credits the supplier, debits the purchase ledger and the adjustment ledgers, and brings the goods into stock. A goods received note only brings goods into stock. Requisitions, quotations and orders change nothing.
You owe = the net amount: products, plus the adjustments that add (VAT, freight), minus those that take off (discounts).
Purchases = the basic amount of the lines, before adjustments. A product can have its own purchase ledger, so one invoice can debit several purchase ledgers.
A cash purchase (the supplier is a cash or bank ledger) credits that cash or bank ledger instead of a supplier, so the money is out at once and no supplier balance appears (Enter a purchase invoice).